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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 406774Generated: October 25, 2026

6-cyclopropyl-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-1,3-oxazinan-2-one → (R)-2-methyl-propane-2-sulfinic acid [(S)-1-(4-bromo-3-methyl-phenyl)-ethyl]amide

https://huagongshe.com/reaction/406774

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-cyclopropyl-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-1,3-oxazinan-2-oneHCID 59635673—
Reactant(R)-2-methyl-propane-2-sulfinic acid [1-(4-bromo-3-methyl-phenyl)ethylidene]-amideHCID 86649415—
Product(R)-2-methyl-propane-2-sulfinic acid [(S)-1-(4-bromo-3-methyl-phenyl)-ethyl]amideHCID 58102400—

Reaction Steps

The title compound was prepared from (R)-2-methyl-propane-2-sulfinic acid [1-(4-bromo-3-methyl-phenyl)-ethylidene]-amide following a procedure analogous to that described in Step 2 of Intermediate 1. LC-MS (Method 5): tR=4.04 min; Mass spectrum (ESI+): m/z=318/320 (Br) [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08754076B2
Source datasetuspto-grants-2014_06
ORD IDord-e451468465004465882b71618067d020
Source noteuspto-grants-2014_06