HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphosgene → (S)-1-Bromo-4-(1-isocyanato-ethyl)-2-methyl-benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | (S)-1-(4-Bromo-3-methylphenyl)ethan-1-amine | HCID 58102381 | — |
| Reactant | 6-cyclopropyl-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-1,3-oxazinan-2-one | HCID 59635673 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-1-Bromo-4-(1-isocyanato-ethyl)-2-methyl-benzene | HCID 86649416 | — |
Reaction Steps
The title compound was prepared from (S)-1-(4-bromo-3-methyl-phenyl)-ethylamine and triphosgene following a procedure analogous to that described in Step 4 of Intermediate 1. Mass spectrum (ESI+): m/z=272/274 (Br) [M+H+MeOH]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08754076B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-7cb1a4eaa57a4ea2a339eee011e1b6cd |
| Source note | uspto-grants-2014_06 |