HRID406937

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID51

alpha-Ketoglutaric acid

C5H6O5

结构：CCOc1cc2c(cc1OC)C(c1cnc(N(C)C)nc1OC)=N[C@@H]1CC[C@@H](O)C[C@H]21

HCID11853488

未命名化合物

PRODUCTS

生成物

结构：CCOc1cc2c(cc1OC)C(c1cnc(N(C)C)nc1OC)=N[C@@H]1CC[C@@H](OC(=O)C(=O)CCC(=O)O)C[C@H]21

HCID131728122

未命名化合物

收率 71%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

(2R,4aR,10bR)-6-(2-Dimethylamino-4-methoxy-pyrimidin-5-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-2-ol ((42.7 mg, 0.1 mmol) are dissolved in 0.5 ml of acetone. 16.1 mg (0.11 mmol) of 2-oxo-pentanedioic acid (dissolved in 0.5 ml of acetone) are added. The crystals are filtered off and dried to obtain 40.6 mg (71%) of the title compound (m.p.: 124° C.).

WORKUP

后处理

filtrationThe crystals are filtered off
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5a7d3c0d8c7d4cc283866888daa63ff7
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08754218B2
来源说明: uspto-grants-2014_06

反应 SMILES

[CH3:1][N:2]([CH3:31])[C:3]1[N:8]=[C:7]([O:9][CH3:10])[C:6]([C:11]2[C:24]3[C:19](=[CH:20][C:21]([O:27][CH2:28][CH3:29])=[C:22]([O:25][CH3:26])[CH:23]=3)[C@@H:18]3[C@@H:13]([CH2:14][CH2:15][C@@H:16]([OH:30])[CH2:17]3)[N:12]=2)=[CH:5][N:4]=1.[O:32]=[C:33]([CH2:37][CH2:38][C:39]([OH:41])=[O:40])[C:34](O)=[O:35]>CC(C)=O>[O:32]=[C:33]([CH2:37][CH2:38][C:39]([OH:41])=[O:40])[C:34]([O:30][C@@H:16]1[CH2:15][CH2:14][C@@H:13]2[C@@H:18]([C:19]3[C:24]([C:11]([C:6]4[C:7]([O:9][CH3:10])=[N:8][C:3]([N:2]([CH3:1])[CH3:31])=[N:4][CH:5]=4)=[N:12]2)=[CH:23][C:22]([O:25][CH3:26])=[C:21]([O:27][CH2:28][CH3:29])[CH:20]=3)[CH2:17]1)=[O:35]