化工社化工社 化学情報印刷レポート · 研究参考用
2-Oxoglutaric Acid → HCID 131728122、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Oxoglutaric Acid | HCID 51 | — |
| 反応物 | (2R,4aR,10bR)-6-(2-Dimethylamino-4-methoxy-pyrimidin-5-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-2-ol | HCID 11853488 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | HCID 131728122 | HCID 131728122 | 71% |
反応手順
(2R,4aR,10bR)-6-(2-Dimethylamino-4-methoxy-pyrimidin-5-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-2-ol ((42.7 mg, 0.1 mmol) are dissolved in 0.5 ml of acetone. 16.1 mg (0.11 mmol) of 2-oxo-pentanedioic acid (dissolved in 0.5 ml of acetone) are added. The crystals are filtered off and dried to obtain 40.6 mg (71%) of the title compound (m.p.: 124° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08754218B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-5a7d3c0d8c7d4cc283866888daa63ff7 |
| 出典メモ | uspto-grants-2014_06 |