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HRID406942

反应详情

EQUATION

反应方程式

HRID 406942 的结构方程式

REACTANTS

反应物

2
结构：Br
HCID260

Hydrogen Bromide

BrH

结构：CCOc1cc2c(cc1OC)C(c1ccc(OC)nc1OC)=N[C@@H]1CC[C@@H](O)C[C@H]21
HCID11258441

未命名化合物

PRODUCTS

生成物

1
结构：Br.CCOc1cc2c(cc1OC)C(c1ccc(OC)nc1OC)=N[C@@H]1CC[C@@H](O)C[C@H]21
HCID67022669

未命名化合物

收率 97%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)CC(C)C
溶剂HCID7909

4-Methyl-2-pentanone

C6H12O

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

(2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-2-ol (1.2 g; 2.9 mmol) is dissolved in 7.2 ml of 4-methyl-2-pentanone. The solution is heated up to 60° C. 350 μl (3.05 mmol) of aqueous HBr (W=47%) are added. After crystallisation the suspension is stirred over night. The crystals are filtered off and dried to obtain 1.38 g (97%) of the title compound (m.p.: 163° C.).

WORKUP

后处理

  1. customAfter crystallisation the suspension
  2. filtrationThe crystals are filtered off
  3. customdried