反应详情

In a round bottom flask, (10 g) 1-tetralone in 20 ml methanol, 15 ml (2 equiv.) trimethyl orthoformate was taken and the mixture was stirred at room temperature. 0.2 ml hexafluoro phosphoric acid (catalytic amount) was added and the mixture was refluxed for 5.5 hrs. The mixture was then cooled at 25-30° C. After completion of reaction dilute the reaction mass by adding 10% NaHCO3 solution and extract with ethyl acetate. The organic layer was washed with NaHCO3 solution. Dry it by adding sodium sulfate, concentrate it on rotavapour to give dark brown colored oily product.

1. temperaturethe mixture was refluxed for 5.5 hrs
2. temperatureThe mixture was then cooled at 25-30° C
3. customAfter completion of reaction
4. additiondilute the reaction mass
5. extractionextract with ethyl acetate
6. washThe organic layer was washed with NaHCO3 solution
7. customDry it
8. additionby adding sodium sulfate
9. concentrationconcentrate it on rotavapour
10. customto give dark brown colored oily product