Cyclopropanemethanamine → US10213427, Example 16

HRID 406984Notes

Reaction equation

HRID 406984 reaction equation
[F:1][C:2]([F:35])([F:34])[CH2:3][NH:4][C:5]([NH:7][C:8]1[CH:9]=[C:10]([N:14]2[C:18]3[CH:19]=[CH:20][C:21]([C:23]4[CH:28]=[CH:27][C:26]([CH:29]([CH3:33])[C:30](O)=[O:31])=[CH:25][CH:24]=4)=[CH:22][C:17]=3[N:16]=[CH:15]2)[CH:11]=[CH:12][CH:13]=1)=[O:6].[CH:36]1([CH2:39][NH2:40])[CH2:38][CH2:37]1>>[CH:36]1([CH2:39][NH:40][C:30](=[O:31])[CH:29]([C:26]2[CH:25]=[CH:24][C:23]([C:21]3[CH:20]=[CH:19][C:18]4[N:14]([C:10]5[CH:11]=[CH:12][CH:13]=[C:8]([NH:7][C:5]([NH:4][CH2:3][C:2]([F:35])([F:34])[F:1])=[O:6])[CH:9]=5)[CH:15]=[N:16][C:17]=4[CH:22]=3)=[CH:28][CH:27]=2)[CH3:33])[CH2:38][CH2:37]1

Participants

3

Reactant 2

HCID 75646CyclopropanemethanamineHCID 679802542-(4-{1-[3-({[(2,2,2-trifluoroethyl)amino]carbonyl]amino)phenyl]-1H-benzimidazol-5-yl}phenyl)propanoic acid

Product 1

HCID 57386675US10213427, Example 16

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 14 starting from 2-(4-{1-[3-({[(2,2,2-trifluoro ethyl)amino]carbonyl}amino)phenyl]-1H-benzimidazol-5-yl}phenyl)propanoic acid (prepared by the procedure for Example 14, step 3) and cyclopropylmethylamine (Aldrich, Cat. No. 359521), LCMS (M+H)+: m/z=536.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-5d45cf382ae84178b140a0c384e34879
Source dataset
uspto-grants-2014_06
Patent number
US08754114B2

Reaction notes

Loading…