3,3,3-Trifluoro-2-hydroxypropanoic acid → HCID 57384357, compound

HRID 407021Notes

Reaction equation

HRID 407021 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[N:16][N:15]4[C:18]([C:21]5[CH:22]=[C:23]([NH:27][C:28]([NH:30][CH2:31][C:32]([F:35])([F:34])[F:33])=[O:29])[CH:24]=[CH:25][CH:26]=5)=[CH:19][N:20]=[C:14]4[CH:13]=3)[CH:9]=[N:8]2)[CH2:3][CH2:2]1.[F:36][C:37]([F:44])([F:43])[CH:38]([OH:42])[C:39](O)=[O:40]>>[F:34][C:32]([F:33])([F:35])[CH2:31][NH:30][C:28]([NH:27][C:23]1[CH:24]=[CH:25][CH:26]=[C:21]([C:18]2[N:15]3[N:16]=[CH:17][C:12]([C:10]4[CH:9]=[N:8][N:7]([CH:4]5[CH2:5][CH2:6][N:1]([C:39](=[O:40])[CH:38]([OH:42])[C:37]([F:44])([F:43])[F:36])[CH2:2][CH2:3]5)[CH:11]=4)=[CH:13][C:14]3=[N:20][CH:19]=2)[CH:22]=1)=[O:29]

Participants

3

Reactant 2

HCID 2448963,3,3-Trifluoro-2-hydroxypropanoic acidHCID 67980436N-{3-[7-(1-piperidin-4-yl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea

Product 1

HCID 57384357HCID 57384357, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 41 starting from N-{3-[7-(1-piperidin-4-yl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]phenyl}-N′-(2,2,2-trifluoroethyl)urea and 3,3,3-trifluoro-2-hydroxypropanoic acid (Lancaster, Cat. No. L07742). LCMS (M+H)+: m/z=611.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-0fba7f03866a45fba78bd5e4c34bef6a
Source dataset
uspto-grants-2014_06
Patent number
US08754114B2

Reaction notes

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