(1R)-1-(2-Fluorophenyl)ethylamine → N-[1-(2-Fluorophenyl)ethyl]-3-[3-(3-{[(methylamino)carbonyl]amino}phenyl)imidazo[1,2-b]pyridazin-7-yl]benzamide

HRID 407083Notes

Reaction equation

HRID 407083 reaction equation
[CH3:1][NH:2][C:3]([NH:5][C:6]1[CH:7]=[C:8]([C:12]2[N:16]3[N:17]=[CH:18][C:19]([C:21]4[CH:22]=[C:23]([CH:27]=[CH:28][CH:29]=4)[C:24](O)=[O:25])=[CH:20][C:15]3=[N:14][CH:13]=2)[CH:9]=[CH:10][CH:11]=1)=[O:4].[F:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[CH:37]([NH2:39])[CH3:38]>>[F:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[CH:37]([NH:39][C:24](=[O:25])[C:23]1[CH:27]=[CH:28][CH:29]=[C:21]([C:19]2[CH:18]=[N:17][N:16]3[C:12]([C:8]4[CH:9]=[CH:10][CH:11]=[C:6]([NH:5][C:3]([NH:2][CH3:1])=[O:4])[CH:7]=4)=[CH:13][N:14]=[C:15]3[CH:20]=2)[CH:22]=1)[CH3:38]

Participants

3

Reactant 2

HCID 2782361(1R)-1-(2-Fluorophenyl)ethylamineHCID 679800673-[3-(3-{[(Methylamino)carbonyl]amino]phenyl)imidazo[1,2-b]pyridazin-7-yl]benzoic acid

Product 1

HCID 57386927N-[1-(2-Fluorophenyl)ethyl]-3-[3-(3-{[(methylamino)carbonyl]amino}phenyl)imidazo[1,2-b]pyridazin-7-yl]benzamide

Procedure

This compound was prepared by using procedure analogous to those described for the synthesis of Example 96, Step 4 starting from 3-[3-(3-{[(methylamino)carbonyl]amino}phenyl)imidazo[1,2-b]pyridazin-7-yl]benzoic acid and 1-(2-fluorophenyl)ethanamine. LCMS (M+H)+: m/z=509.2

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-e99d17e330a84c0ab2298a026485303a
Source dataset
uspto-grants-2014_06
Patent number
US08754114B2

Reaction notes

Loading…