Ammonia → HCID 68211002, compound

HRID 407099Notes

Reaction equation

HRID 407099 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14](F)=[C:13]([N+:18]([O-:20])=[O:19])[CH:12]=2)=[O:9])=[CH:4][CH:3]=1.O.[NH2:22][NH2:23].N>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([NH:22][NH2:23])=[C:13]([N+:18]([O-:20])=[O:19])[CH:12]=2)=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 24654Hydrazine hydrate (1:1)HCID 4674743HCID 4674743, compound

Product 1

HCID 68211002HCID 68211002, compoundYield 84%

Conditions

Temperature
75 °C

Procedure

Dissolving 20 (6.5 g, 22 mmol) in hot alcohol (150 mL) and adding slowly a mixture of 100% hydrazine hydrate (1.6 mL), concentrated aqueous ammonia (1.7 mL) and alcohol (5 mL). The mixture was stirred at 75° C. for 2 h. The reaction mixture was filtered to give 21 (5.68 g, 84% yield).

Workup

  1. additionadding slowly
  2. filtrationThe reaction mixture was filtered

Sources & evidence

ORD record
ord-ce7f151719884a658a4db9caecb41757
Source dataset
uspto-grants-2014_06
Patent number
US08754219B2

Reaction notes

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