反应详情

温度

170 °C

Crude 5-fluoro-2-[1-(4-methoxy-benzyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-oxazolo[5,4-b]pyridine from Step 2 was dissolved in TFA (0.5 mL) and heated by microwave to 170° C. for 25 min. The volatiles were then removed in vacuo and the resulting residue was purified by HPLC to afford 5-fluoro-2-(1H-pyrrolo[2,3-b]pyridin-5-yl)-oxazolo[5,4-b]pyridine (2.5 mg, 9.8 μmol, 6% yield). ES MS (M+H+)=255; 1H NMR δ (ppm) (DMSO-d6): 12.18 (1H, s), 9.04 (1H, d, J=2.10 Hz), 8.76 (1H, d, J=2.06 Hz), 8.44 (1H, dd, J=8.39, 7.10 Hz), 7.67 (1H, t, J=2.75 Hz), 7.31 (1H, d, J=8.40 Hz), 6.68 (1H, d, J=3.43 Hz); HRMS m/z 255.0675 (C13H7FN4O+H+ requires 255.0677).

1. customThe volatiles were then removed in vacuo
2. customthe resulting residue was purified by HPLC