1-(3-Chloropropyl)-pyrrolidine → 4-Azoniaspiro[3,4]octane chloride

HRID 407277Notes

Reaction equation

HRID 407277 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][CH2:6]1>CO>[Cl-:1].[CH2:2]1[N+:5]2([CH2:9][CH2:8][CH2:7][CH2:6]2)[CH2:4][CH2:3]1

Participants

3

Reactant 1

HCID 113210281-(3-Chloropropyl)-pyrrolidine

Product 1

HCID 674420294-Azoniaspiro[3,4]octane chloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(3-Chloropropyl)pyrrolidine (1.142 g) was dissolved in methanol (38 ml) and the solution refluxed overnight. The solution was evaporated to dryness on a rotary evaporator to give 4-azoniaspiro[3,4]octane chloride as an impure oil.

Workup

  1. temperaturethe solution refluxed overnight
  2. customThe solution was evaporated to dryness on a rotary evaporator

Sources & evidence

ORD record
ord-6b41d7fbc0494560a3b85402351705d4
Source dataset
uspto-grants-2014_06
Patent number
US08754240B2

Reaction notes

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