1-(3-Chloropropyl)-pyrrolidine → 4-Azoniaspiro[3,4]octane chloride
Reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][CH2:6]1>O>[Cl-:1].[CH2:2]1[N+:5]2([CH2:9][CH2:8][CH2:7][CH2:6]2)[CH2:4][CH2:3]1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 20 °C
Procedure
An aqueous solution of 4-azoniaspiro[3,4]octane chloride was prepared by adding 1-(3-Chloropropyl)pyrrolidine (128 ml) to water (100 ml) at 94° C. over 25 minutes. The mixture was stirred for a further 5 minutes to give a clear yellow solution. This was cooled to 20° C. and stored in a bottle. Line washes of water (2×25 ml) were applied.
Workup
- customto give a clear yellow solution
Sources & evidence
- ORD record
- ord-472bb1f6e5ae4ec6874eeba1ff218b05
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08754240B2
Reaction notes
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