1-(3-Chloropropyl)-pyrrolidine → 4-Azoniaspiro[3,4]octane chloride

Participants

Reaction Conditions

Reaction Steps

An aqueous solution of 4-azoniaspiro[3,4]octane chloride was prepared by adding 1-(3-Chloropropyl)pyrrolidine (128 ml) to water (100 ml) at 94° C. over 25 minutes. The mixture was stirred for a further 5 minutes to give a clear yellow solution. This was cooled to 20° C. and stored in a bottle. Line washes of water (2×25 ml) were applied.

Provenance & Evidence