2,4-Dichloropyrimidine → 1-(3-(2-Chloropyrimidin-4-yl)phenyl)piperidin-4-one

HRID 40732Notes

Reaction equation

HRID 40732 reaction equation
CC1(C)C(C)(C)OB([C:9]2[CH:10]=[C:11]([N:15]3[CH2:20][CH2:19][C:18](=[O:21])[CH2:17][CH2:16]3)[CH:12]=[CH:13][CH:14]=2)O1.[Cl:23][C:24]1[N:29]=[C:28](Cl)[CH:27]=[CH:26][N:25]=1>>[Cl:23][C:24]1[N:29]=[C:28]([C:9]2[CH:10]=[C:11]([N:15]3[CH2:16][CH2:17][C:18](=[O:21])[CH2:19][CH2:20]3)[CH:12]=[CH:13][CH:14]=2)[CH:27]=[CH:26][N:25]=1

Participants

3

Reactant 2

HCID 775312,4-DichloropyrimidineHCID 68777237HCID 68777237, compound

Product 1

HCID 866478711-(3-(2-Chloropyrimidin-4-yl)phenyl)piperidin-4-one

Procedure

1-(3-(2-Chloropyrimidin-4-yl)phenyl)piperidin-4-one was prepared from 1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-one and 2,4-dichloropyrimidine according to procedure B.

Sources & evidence

ORD record
ord-f8711b0598c14a4a8d6fa58582c0dbb3
Source dataset
uspto-grants-2013_09
Patent number
US08530480B2

Reaction notes

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