4-Methylmorpholine → HCID 178434659, compound

HRID 407322Notes

Reaction equation

HRID 407322 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]1[S:9][C:10]2[CH:16]=[C:15]([S:17](Cl)(=[O:19])=[O:18])[CH:14]=[CH:13][C:11]=2[N:12]=1.[CH3:21][N:22]([CH3:27])[CH2:23][CH2:24][CH2:25][NH2:26].CN1CCOCC1>CO>[CH3:21][N:22]([CH3:27])[CH2:23][CH2:24][CH2:25][NH:26][S:17]([C:15]1[CH:14]=[CH:13][C:11]2[N:12]=[C:8]([C:3]3[C:4]([CH3:7])=[N:5][NH:6][C:2]=3[NH2:1])[S:9][C:10]=2[CH:16]=1)(=[O:19])=[O:18]

Participants

5

Reactant 3

HCID 79724-MethylmorpholineHCID 7993N,N-Dimethyl-1,3-propanediamineHCID 178434647HCID 178434647, compound

Product 1

HCID 178434659HCID 178434659, compoundYield 2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

the title compound (2 mg) was prepared from crude 2-(5-amino-3-methyl-1H-pyrazol-4-yl)benzothiazole-6-sulfonyl chloride (100 mg, 0.30 mmol), N1,N1-dimethylpropane-1,3-diamine (77 μL, 0.60 mmol) and PS-NMM (0.320 g, 0.60 mmol) in 5 mL of methanol. MS (m/z, ES+): 395.3 (M+1, 100%). Yield=2%.

Sources & evidence

ORD record
ord-b4488ce5c3184d28a584d84a0f0111bc
Source dataset
uspto-grants-2014_06
Patent number
US08754233B2

Reaction notes

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