Formic Acid → HCID 178522646, compound

HRID 407366Notes

Reaction equation

HRID 407366 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:11]([NH2:15])=[N:12][NH:13][CH:14]=1.[CH:16](O)=[O:17]>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:11]([NH:15][CH:16]=[O:17])=[N:12][NH:13][CH:14]=1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 178509260HCID 178509260, compound

Product 1

HCID 178522646HCID 178522646, compoundYield 90%

Procedure

A solution of 4-benzothiazol-2-yl-1H-pyrazol-3-ylamine (1.1 g, 5.0 mmol) in 20 mL of formic acid was heated to 70° C. overnight. The formic acid was evaporated under reduced pressure and the resulting crude material was recrystallized from ethanol to yield 1.1 g (90%) of N-(4-benzothiazol-2-yl-1H-pyrazol-3-yl)-formamide.

Workup

  1. customThe formic acid was evaporated under reduced pressure
  2. customthe resulting crude material was recrystallized from ethanol

Sources & evidence

ORD record
ord-95301b1e407147a2b57870a25eb56f71
Source dataset
uspto-grants-2014_06
Patent number
US08754233B2

Reaction notes

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