Ammonium Hydroxide → (1R,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexane-1-carboxamide

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Reaction Steps

A 250 mL flask was purged with nitrogen, left under a nitrogen atmosphere, and charged with 13.0 g (0.0641 mol) of (1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarbonyl chloride. While stirring 130 mL of 29% ammonium hydroxide solution was added to the flask. A white precipitate quickly formed, and after stirring overnight the fine white slurry was suction filtered. The filter cake was washed with water (3×50 mL) then dried in a vacuum oven (RT, 5 mm Hg, 3 days) to provide (1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxamide as a white solid with the following spectroscopic properties.

Provenance & Evidence