反应详情

A 250 mL flask was purged with nitrogen, left under a nitrogen atmosphere, and charged with 13.0 g (0.0641 mol) of (1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarbonyl chloride. While stirring 130 mL of 29% ammonium hydroxide solution was added to the flask. A white precipitate quickly formed, and after stirring overnight the fine white slurry was suction filtered. The filter cake was washed with water (3×50 mL) then dried in a vacuum oven (RT, 5 mm Hg, 3 days) to provide (1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxamide as a white solid with the following spectroscopic properties.

1. customA 250 mL flask was purged with nitrogen
2. waitleft under a nitrogen atmosphere
3. additionwas added to the flask
4. customA white precipitate quickly formed
5. filtrationfiltered
6. washThe filter cake was washed with water (3×50 mL)
7. customthen dried in a vacuum oven (RT, 5 mm Hg, 3 days)