Urea → 7,8-dichloroquinazolin-2,4(1H,3H)-dione

HRID 40765Notes

Reaction equation

HRID 40765 reaction equation
[NH2:1][C:2]1[C:10]([Cl:11])=[C:9]([Cl:12])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].[NH2:13][C:14](N)=[O:15]>>[Cl:12][C:9]1[C:10]([Cl:11])=[C:2]2[C:3]([C:4](=[O:5])[NH:13][C:14](=[O:15])[NH:1]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 1176UreaHCID 43395852-Amino-3,4-dichlorobenzoic acid

Product 1

HCID 196043157,8-dichloroquinazolin-2,4(1H,3H)-dione

Procedure

Prepared according to general method C from 2-amino-3,4-dichlorobenzoic acid (2.23 g) and urea (6.49 g). Yield 2.18 g (87%) of a solid. 1H-NMR (DMSO-δ6) δ (ppm) 11.64 (br s, 1H), 10.87 (br s, 1H), 7.86 (d, J=8.5 Hz, 1H), 7.43 (d, J=8.5 Hz, 1H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-79ea5cf4ea604b1f8c5c53097c86851e
Source dataset
uspto-grants-2013_09
Patent number
US08530486B2

Reaction notes

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