反应详情

A 50-mL single-neck round-bottomed flask equipped with a magnetic stirrer was charged with 116a (1.6 g, 4.4 mmol), acetic anhydride (10 mL), and triethylamine (1 mL). The reaction mixture was stirred at room temperature for 1 h and concentrated under reduced pressure. The residue was purified by silica-gel column chromatography eluting with 30:1 dichloromethane/methanol to afford 116b as a brown solid (1.4 g, 82%). MS: [M+H]+ 404.3.

1. customA 50-mL single-neck round-bottomed flask equipped with a magnetic stirrer
2. concentrationconcentrated under reduced pressure
3. customThe residue was purified by silica-gel column chromatography
4. washeluting with 30:1 dichloromethane/methanol