反应详情

A solution of 5-bromo-1-methyl-3-(5-methyl-1H-pyrazol-3-ylamino)pyridin-2(1H)-one 118a (2.8 g, 9.9 mmol) in anhydrous DMF (10 mL) was treated with 60% dispersion of NaH in mineral oil (0.51 g, 13 mmol) while stirring under nitrogen. After the resulting effervescence ceased, the reaction was stirred for an additional 30 minutes. At this time the reaction was treated with iodomethane (0.98 g, 7.0 mmol) with continued stirring under nitrogen for 2 hours. Water (50 mL) was added slowly and the mixture was filtered. The filtrate was extracted with ethyl acetate (3×30 mL). The combined extract was concentrated under reduced pressure and the residue was purified by flush column chromatography eluting with 3:1 petroleum ether/ethyl acetate to afford 119a (0.70 g, 24%). MS: [M+H]+ 297.

1. stirringthe reaction was stirred for an additional 30 minutes
2. stirringwith continued stirring under nitrogen for 2 hours
3. filtrationthe mixture was filtered
4. extractionThe filtrate was extracted with ethyl acetate (3×30 mL)
5. extractionThe combined extract
6. concentrationwas concentrated under reduced pressure
7. customthe residue was purified
8. customby flush column chromatography
9. washeluting with 3:1 petroleum ether/ethyl acetate