참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetate | HCID 175 | — |
| 반응물 | 1-Ethyl-1h-pyrazol-4-amine | HCID 7018640 | — |
| 반응물 | 3,5-Dibromo-1-methyl-1H-pyrazin-2-one | HCID 13062969 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 5-Bromo-3-(1-ethyl-1H-pyrazol-4-ylamino)-1-methylpyrazin-2(1H)-one | HCID 58043741 | 60% |
반응 단계
A 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer and reflux condenser was charged with 123b (500 mg, 4.5 mmol), 3,5-dibromo-1-methylpyrazin-2(1H)-one (2.40 g, 9.0 mmol), DIPethyl acetate (3 mL), and isopropanol (50 mL). The mixture was heated at 100° C. for 2 h. It was then cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure to afford 123c (802 mg, 60%) as a white solid. MS-ESI: [M+H]+ 298.0
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08754077B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_06 |
|---|
| ORD ID | ord-e34ce01c762e4a62a6851236c675e852 |
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| 출처 메모 | uspto-grants-2014_06 |
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