反应详情

A 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer was charged with acetonitrile (50 mL), TFA (10 mL), 3-bromopyridin-2-ol (4.0 g, 11.56 mmol), N-iodosuccinimide (5.2 g, 11.56 mmol). The mixture was stirred at room temperature for 15 h. The mixture was diluted with water (100 mL) and resulting white solid was collected by filtration to afford 142a (6.6 g, 96%) as a white solid. MS-ESI: [M+H]+ 300

1. customA 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer
2. customresulting white solid
3. filtrationwas collected by filtration