反应详情

温度

50 °C

A mixture of 151c (400 mg, 1.48 mmol) and methanol (30 mL) was stirred at 50° C. for 16h. The mixture was the concentrated under reduced pressure. The residue was diluted with water (80 mL) and extracted with ethyl acetate (3×50 mL). The combined organic layer was dried over Na2SO4 and concentrated under reduced pressure to afford 151d (300 mg, 90%) as a yellow solid. MS-ESI: [M+H]+ 225.3

1. concentrationconcentrated under reduced pressure
2. additionThe residue was diluted with water (80 mL)
3. extractionextracted with ethyl acetate (3×50 mL)
4. dry with materialThe combined organic layer was dried over Na2SO4
5. concentrationconcentrated under reduced pressure