Ethyl 2-(5-((Isopropylamino)methyl)-3-nitro-1H-pyrazol-1-yl)acetate → 5-Isopropyl-2-nitro-4,5-dihydropyrazolo[1,5-a]pyrazin-6(7H)-one

Participants

Reaction Conditions

Reaction Steps

A mixture of 151c (400 mg, 1.48 mmol) and methanol (30 mL) was stirred at 50° C. for 16h. The mixture was the concentrated under reduced pressure. The residue was diluted with water (80 mL) and extracted with ethyl acetate (3×50 mL). The combined organic layer was dried over Na2SO4 and concentrated under reduced pressure to afford 151d (300 mg, 90%) as a yellow solid. MS-ESI: [M+H]+ 225.3

Provenance & Evidence