Hydrochloric Acid → HCID 68575137, compound

Participants

Reaction Steps

To a suspension of 2,4-diamino-6-ethyl-5-(3-(6-chloroquinolin-4-yloxy)propoxy)pyrimidine (0.5608 g, 1.5 mmol) in methanol (1 mL) was added two equivalents of concentrated HCl. The titled compound was obtained, after trituration of the reaction mixture with diethyl ether, as a off-white crystalline solid (0.6366 g, 95%). 1H NMR (500 MHz, DMSO-d6): 1.09 (3H, t, J=7.7 Hz), 2.43 (2H, m), 2.48 (2H, m), 3.99 (2H, t, J=6.2 Hz), 4.70 (2H, t, J=5.9 Hz), 7.55 (2H, bs), 7.64 (1H, d, J=6.6 Hz), 7.95 (1H, s), 3.15 (1H, dd, J=9.1, 2.4 Hz), 8.37 (2H, m), 8.41 (1H, d, J=9.1 Hz), 9.22 (1H, d, J=6.5 Hz), 12.80 (1H, s).

Provenance & Evidence