反应详情

To a suspension of 2,4-diamino-6-ethyl-5-(3-(6-chloroquinolin-4-yloxy)propoxy)pyrimidine (0.5608 g, 1.5 mmol) in methanol (1 mL) was added two equivalents of concentrated HCl. The titled compound was obtained, after trituration of the reaction mixture with diethyl ether, as a off-white crystalline solid (0.6366 g, 95%). 1H NMR (500 MHz, DMSO-d6): 1.09 (3H, t, J=7.7 Hz), 2.43 (2H, m), 2.48 (2H, m), 3.99 (2H, t, J=6.2 Hz), 4.70 (2H, t, J=5.9 Hz), 7.55 (2H, bs), 7.64 (1H, d, J=6.6 Hz), 7.95 (1H, s), 3.15 (1H, dd, J=9.1, 2.4 Hz), 8.37 (2H, m), 8.41 (1H, d, J=9.1 Hz), 9.22 (1H, d, J=6.5 Hz), 12.80 (1H, s).