反应详情

温度

160 °C

1.4 g (II) are placed in 10 ml dioxane, then first 3.6 ml diisopropylethylamine are added followed by 1 g 1-aminocyclopropanemethanol (cf. 8.2). The reaction mixture is heated to 160° C. until there is no further reaction, then cooled and evaporated down. The residue is treated with cyclohexane/ethyl acetate (8:2) in the ultrasound bath and the solid is suction filtered and dried. 1.24 g (III-4) are obtained in the form of a solid. Analytical HPLC-MS (method A): RT=1.01 min.

1. customno further reaction
2. temperaturecooled
3. customevaporated down
4. additionThe residue is treated with cyclohexane/ethyl acetate (8:2) in the ultrasound bath
5. filtrationfiltered
6. customdried
7. custom1.24 g (III-4) are obtained in the form of a solid