HCID 86648151, compound → HCID 178518923, compound

HRID 408092Notes

Reaction equation

HRID 408092 reaction equation
C(O)(=O)/C=C/C(O)=O.[Cl:9][C:10]1[N:15]=[N:14][C:13]([O:16]C(O)C)=[C:12]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:11]=1>Br>[Cl:9][C:10]1[N:15]=[N:14][C:13]([OH:16])=[C:12]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:11]=1

Participants

3

Reactant 1

HCID 86648151HCID 86648151, compound

Product 1

HCID 178518923HCID 178518923, compoundYield 221.2%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

15 g (6-chloro-4-piperazin-1-yl-pyridazin-3-yloxy)-ethanol fumarate are suspended in 90 ml hydrogen bromide (48%). The reaction mixture is stirred for 1 hour at reflux temperature and evaporated to dryness. 19 g product are obtained as the hydrobromide. M.p.=35° C.

Workup

  1. temperatureat reflux temperature
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-990fe310572d46c686d659d736a3b3d8
Source dataset
uspto-grants-2014_06
Patent number
US08759326B2

Reaction notes

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