反应详情

To a stirring suspension of 2,4-diamino-6-ethyl-5-(3-(7-fluoro-2-methylquinolin-4-yloxy)propoxy)pyrimidine (0.3714 g, 1 mmol) in methanol (10 mL) was added one equivalent of hydrochloric acid at 25° C. After evaporation of solvent and trituration with diethyl ether, product was obtained as white crystalline solid (0.3834 g, 94%). m.p. >200° C., 1H NMR (400 MHz, DMSO-d6): 0.99 (3H, t, J=7.6 Hz), 2.35 (2H, m), 2.44 (2H, q, J=7.6 Hz), 2.64 (3H, s), 3.97 (2H, t, J=5.8 Hz), 4.45 (2H, t, J=5.5 Hz), 7.07 (1H, s), 7.45 (3H, m), 7.64 (1H, d, J=10.5 Hz), 7.90 (1H, bs), 8.19 (1H, dd, J=8.9, 6.3 Hz), 8.33 (1H, bs), 12.30 (1H, bs).

1. customAfter evaporation of solvent and trituration with diethyl ether