反应详情

温度

60 °C

Selenium dioxide (1.6 g, 14 mmol, 1.3 eq) was suspended in dioxan (50 mL) and was heated to 60° C. At this temperature 7-bromoquinaldine (2.5 g, 11.2 mmol) was introduced and the mixture was left at 80° C. for 3 hours. After cooling the mixture to room temperature, the crude slurry was filtered on celite, eluted with dioxan and concentrated under reduced pressure. The product was obtained pure as a brown solid (3.3 g, >98%) that was used without furter purification.

1. temperatureAfter cooling the mixture to room temperature
2. filtrationthe crude slurry was filtered on celite
3. washeluted with dioxan
4. concentrationconcentrated under reduced pressure