HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 3-Dimethylamino-1-fluoro-7-bromo-10-Boc-phenothiazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | 3,7-Dibromo-1-fluoro-10-Boc-phenothiazine | HCID 68227324 | — |
| Catalyst | (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium | HCID 6505921 | — |
| Product | 3-Dimethylamino-1-fluoro-7-bromo-10-Boc-phenothiazine | HCID 68227340 | — |
Reaction Steps
To a stirred solution of 3,7-dibromo-1-fluoro-10-Boc-phenothiazine (8) (475 mg, 1 mmol) in touene (10 mL) Pd(dba)2 (28.9 mg, 0.05 mmol), BINAP (22.5 mg, 0.035 mmol), Cs2CO3 (652 mg, 2 mmol) and dimethylamine (0.6 mL, 1.2 mmol) were added. The mixture was refluxed for 24 h. After that reaction mixture was filtered, solvent was removed under vacuum. Product was used without additional purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759336B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-4ec46acf52b04c1aacb04176e326f276 |
| Source note | uspto-grants-2014_06 |