反应详情

To a stirred solution of 3,7-dibromo-1-fluoro-10-Boc-phenothiazine (8) (475 mg, 1 mmol) in touene (10 mL) Pd(dba)2 (28.9 mg, 0.05 mmol), BINAP (22.5 mg, 0.035 mmol), Cs2CO3 (652 mg, 2 mmol) and dimethylamine (0.6 mL, 1.2 mmol) were added. The mixture was refluxed for 24 h. After that reaction mixture was filtered, solvent was removed under vacuum. Product was used without additional purification.

1. temperatureThe mixture was refluxed for 24 h
2. filtrationAfter that reaction mixture was filtered
3. customsolvent was removed under vacuum
4. customProduct was used without additional purification