反应详情

温度

25 °C

A suspension of the ethyl ester obtained in step (c) (0.314 g, 0.65 mmol) and aqueous KOH solution (10 equiv) was stirred at 25° C. overnight. The solution was neutralized by addition of dilute HCl. The precipitate formed was separated by filtration and dried in an oven at 80° C. to give a light yellow solid (0.2487 g, 84%). 1H NMR (400 MHz, DMSO-d6): 0.91 (3H, t, J=7.5 Hz), 1.98 (2H, m), 2.29 (4H, m), 2.41 (2H, t, J=7.2 Hz), 2.56 (3H, s), 3.86 (2H, t, J=5.5 Hz), 4.05 (2H, t, J=5.9 Hz), 4.40 (2H, t, J=5.3 Hz), 5.67 (2H, s), 6.24 (2H, s) 6.94 (1H, s), 7.33 (2H, m), 7.75 (1H, d, J=9.1 Hz).

1. customThe precipitate formed
2. customwas separated by filtration
3. customdried in an oven at 80° C.