反应详情

To a stirring suspension of 2,4-diamino-6-ethyl-5-(3-(6-(3-ethoxycarbonylpropoxy)-2-methylquinolin-4-yloxy)propoxy)pyrimidine obtained from step (c) (0.179 g, 0.37 mmol) in ethanol (0.5 mL) was added one equivalent of hydrochloric acid at 25° C. After evaporation of solvent and trituration with acetone, the product was obtained as white crystalline solid (0.117 g, 61%). 1H NMR (400 MHz, DMSO-d6): 0.90 (3H, t, J=7.5 Hz), 1.15 (3H, t, J=7.0 Hz), 2.00 (2H, m), 2.35 (4H, m), 2.40 (2H, m), 2.70 (3H, s), 3.85 (2H, t, J=6.0 Hz), 4.02 (2H, q, J=7.0 Hz), 4.10 (2H, t, J=6.0 Hz), 4.52 (2H, m), 7.25 (s, 1H), 7.42 (3H, m), 7.90 (1H, bs), 8.00 (1H, d, J=10 Hz), 8.30 (1H, bs).

1. customAfter evaporation of solvent and trituration with acetone