Bromine → α-Bromo-2-chloro-6-fluorobenzenepropanal

HRID 408490Notes

Reaction equation

HRID 408490 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:5]=1[CH2:11][CH2:12][CH:13]=[O:14]>ClCCl>[Br:1][CH:12]([CH2:11][C:5]1[C:6]([F:10])=[CH:7][CH:8]=[CH:9][C:4]=1[Cl:3])[CH:13]=[O:14]

Participants

4

Reactant 2

HCID 24408BromineHCID 282762173-(2-Chloro-6-fluorophenyl)propanal

Product 1

HCID 57464354α-Bromo-2-chloro-6-fluorobenzenepropanal

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of bromine (11 g, 0.081 mol) in dichloromethane (50 mL) was slowly added to a solution of 3-(2-chloro-6-fluoro-phenyl)-propionaldehyde (15 g, 0.081 mol) in dichloromethane (250 mL) at 0° C. The mixture was stirred overnight at room temperature and then the solvent was removed to give the crude product which was used directly in the next step.

Workup

  1. customthe solvent was removed

Sources & evidence

ORD record
ord-03e187d00270447fafd108527d54a440
Source dataset
uspto-grants-2014_06
Patent number
US08759335B2

Reaction notes

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