HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → α-Bromo-2-chloro-6-fluorobenzenepropanal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 3-(2-Chloro-6-fluorophenyl)propanal | HCID 28276217 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | α-Bromo-2-chloro-6-fluorobenzenepropanal | HCID 57464354 | — |
Reaction Steps
A solution of bromine (11 g, 0.081 mol) in dichloromethane (50 mL) was slowly added to a solution of 3-(2-chloro-6-fluoro-phenyl)-propionaldehyde (15 g, 0.081 mol) in dichloromethane (250 mL) at 0° C. The mixture was stirred overnight at room temperature and then the solvent was removed to give the crude product which was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759335B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-03e187d00270447fafd108527d54a440 |
| Source note | uspto-grants-2014_06 |