Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 1-(1,3-Dioxaindan-5-yl)cyclopropane-1-carboxylic acid | HCID 14349608 | — |
| Reactant | HCID 60027522 | HCID 60027522 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 58609788 | HCID 58609788 | — |
Reaction Steps
5-(2-Methoxy-pyridin-3-ylmethyl)-thiazol-2-ylamine (221 mg, 1.00 mmol) and 1-benzo[1,3]dioxol-5-yl-cyclopropanecarboxylic acid (206 g, 1.00 mmol) were dissolved in acetonitrile (5 mL) containing triethylamine (0.421 mL, 3.00 mmol). O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU, 760 mg, 2.0 mmol) was added and the solution was allowed to stir at 78° C. for 12 hours. An aliquot of the crude product was purified by reverse-phase preparative liquid chromatography. ESI-MS m/z calc. 409.1. found; 410.3 (M+1)+ Retention time 3.23 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08759335B2 |
|---|
| Source dataset | uspto-grants-2014_06 |
|---|
| ORD ID | ord-8deebf8d20864f25b370522d35932f4a |
|---|
| Source note | uspto-grants-2014_06 |
|---|
