Imidazo[1,2-a]pyridine-7-methanol → Imidazo[1,2-A]pyridine-7-carbaldehyde

HRID 408571Notes

Reaction equation

HRID 408571 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[CH:8][C:7]([CH2:10][OH:11])=[CH:6][C:5]=12>C(Cl)(Cl)Cl.O=[Mn]=O>[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[CH:8][C:7]([CH:10]=[O:11])=[CH:6][C:5]=12

Participants

4

Reactant 1

HCID 11051824Imidazo[1,2-a]pyridine-7-methanol

Product 1

HCID 11029972Imidazo[1,2-A]pyridine-7-carbaldehyde

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6212ChloroformSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of imidazo[1,2-a]pyridin-7-yl-methanol (1 eq.) in chloroform was added MnO2 (10 eq.). The dark suspension was heated at 60° C. for 30 min, filtered through a pad of celite and the solvent removed under reduced pressure to afford imidazo[1,2-a]pyridine-7-carbaldehyde which was used as such without further purification.

Workup

  1. filtrationfiltered through a pad of celite
  2. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-87bbdba7e51c4a438546d48ff8f8ffc9
Source dataset
uspto-grants-2014_06
Patent number
US08759334B2

Reaction notes

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