Benzo[d]thiazol-5-ylmethanol → 1,3-Benzothiazole-5-carbaldehyde

HRID 408575Notes

Reaction equation

HRID 408575 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][OH:11])=[CH:9][C:4]=2[N:3]=[CH:2]1>C(Cl)Cl.O=[Mn]=O>[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]=[O:11])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 1

HCID 22281733Benzo[d]thiazol-5-ylmethanol

Product 1

HCID 218737181,3-Benzothiazole-5-carbaldehyde

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Conditions

Temperature
20 °C

Procedure

To a solution of benzothiazol-5-yl-methanol (1 eq.) in DCM was added MnO2 (10 eq.). The dark suspension was stirred at 20° C. for 15 h, filtered through a pad of celite and the solvent removed under reduced pressure to afford benzothiazole-5-carbaldehyde which was used as such without further purification.

Workup

  1. filtrationfiltered through a pad of celite
  2. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-369831751b674dc4b9a51dbd8cf70f4a
Source dataset
uspto-grants-2014_06
Patent number
US08759334B2

Reaction notes

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