HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 408581Generated: October 28, 2026
Hydrochloric Acid → (2R)-2-Methylazetidine-2-carboxylic acid hydrochloride
https://huagongshe.com/reaction/408581
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-1-(4-bromo-benzoyl)-2-methyl-azetidine-2-carboxylic acid | HCID 70557656 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (2R)-2-Methylazetidine-2-carboxylic acid hydrochloride | HCID 70557227 | — |
Reaction Steps
After a chiral separation, Intermediate 33 (1 eq.) (100% ee) was solubilised in dioxane. A solution of HCl (4N) in dioxane was added and the reaction was stirred at 20° C. for 15 h. The solvent was removed under reduced pressure and the crude was crystallised in a mixture of DCM/iPr2O/pentane to afford (R)-2-methyl-azetidine-2-carboxylic acid hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08759334B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-613d60aa3af1479f8bf3358daa5e2b88 |
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| Source note | uspto-grants-2014_06 |
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