Methanol → Methyl azetidine-2-carboxylate hydrochloride

HRID 408610Notes

Reaction equation

HRID 408610 reaction equation
[NH:1]1[CH2:4][CH2:3][CH:2]1[C:5]([OH:7])=[O:6].S(Cl)([Cl:10])=O.[CH3:12]O>>[ClH:10].[CH3:12][O:6][C:5]([CH:2]1[CH2:3][CH2:4][NH:1]1)=[O:7]

Participants

4

Reactant 3

HCID 887MethanolHCID 17288Azetidinecarboxylic AcidHCID 24386Thionyl Chloride

Product 1

HCID 22476057Methyl azetidine-2-carboxylate hydrochloride

Conditions

Temperature
20 °C

Procedure

To a solution of azetidine-2-carboxylic acid (1 eq.) in MeOH at 0° C. was added dropwise thionyl chloride (2.5 eq.). The reaction was stirred at 20° C. for 15 h. The crude was concentrated under reduced pressure and used as such without further purification.

Workup

  1. concentrationThe crude was concentrated under reduced pressure
  2. customsuch without further purification

Sources & evidence

ORD record
ord-7e083845b2e44d96834f03e73cf5b337
Source dataset
uspto-grants-2014_06
Patent number
US08759334B2

Reaction notes

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