反应详情

温度

20 °C

To a solution of 2-bromo-propionic acid ethyl ester (17.90 mL, 1 eq.) in 250 mL of MeCN were added benzylamine (13.45 mL, 0.9 eq.) and potassium carbonate (28.60 g, 1.5 eq.). The reaction was refluxed for 2 h then cooled to 20° C. The crude was filtered, washed with EtOAc. The filtrate was concentrated under reduced pressure, then purified by chromatography on silica gel (elution with heptane/EtOAc: 9/1 to 7/3) to afford 2-benzylamino-propionic acid ethyl ester (24.74 g, yield=97%).

1. temperatureThe reaction was refluxed for 2 h
2. filtrationThe crude was filtered
3. washwashed with EtOAc
4. concentrationThe filtrate was concentrated under reduced pressure
5. custompurified by chromatography on silica gel (elution with heptane/EtOAc: 9/1 to 7/3)