Benzaldehyde → Benzyl-(4-chloro-2-methylquinolin-6-yl)amine

Participants

Reaction Steps

6-Amino-4-chloroquinoline (0.1 g; see step (ii) above), benzaldehyde (0.055 g) and sodium tnacetoxyborohydride (0.22 g) in 1,2-dichloroethane was stirred overnight. The mixture was diluted with dichloromethane and washed with water then dried (MgSO4), filtered and evaporated. The residue was purified by chromatography on silica eluting with a mixture of ethyl acetate and pentane. The desired fractions were concentrated and the sample evaporated to dryness to give the title compound as an oil.

Provenance & Evidence