反应详情

4-Chloro-2-methyl-6-phenoxyquinoline (0.2 g; see Preparation 3 above) and 3-benzyl-pyrrolidine (0.3 g) in 2-ethoxyethanol (4 mL) were heated in a microwave to 200° C. for 20 minutes. The mixture was diluted with 1 N sodium hydroxide and extracted with ethyl acetate, dried (MgSO4), filtered and evaporated. The residue was purified by preparative HPLC, the relevant fractions combined and evaporated to give a clear oil which was acidified with concentrated hydrochloric acid and then evaporated. Trituration with ether gave the title compound as a white powder.

1. extractionextracted with ethyl acetate
2. dry with materialdried (MgSO4)
3. filtrationfiltered
4. customevaporated
5. customThe residue was purified by preparative HPLC
6. customevaporated
7. customto give a clear oil which
8. customevaporated