HCID 25115641, compound → HCID 68725752, compound

HRID 408668Notes

Reaction equation

HRID 408668 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]=[C:14]([CH3:19])[CH:13]=[C:12]2[N:20]1[CH2:24][CH2:23][CH:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:21]1)C1C=CC=CC=1>[Pd].C(O)C>[CH3:19][C:14]1[CH:13]=[C:12]([N:20]2[CH2:24][CH2:23][CH:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH2:21]2)[C:11]2[C:16](=[CH:17][CH:18]=[C:9]([OH:8])[CH:10]=2)[N:15]=1

Participants

4

Reactant 1

HCID 25115641HCID 25115641, compound

Product 1

HCID 68725752HCID 68725752, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

6-Benzyloxy-2-methyl-4-(3-phenylpyrrolidin-1-yl)quinoline (0.3 g; see Example 2 above) and palladium on carbon (10%; 0.2 g) in ethanol (8 mL) was stirred under hydrogen for 3 hours. The mixture was filtered and then concentrated to give the title compound as a yellow oil, which was used without further purification.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-b6db66f52fb9475c974a9d897396be52
Source dataset
uspto-grants-2014_06
Patent number
US08759348B2

Reaction notes

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