Dimethylformamide → HCID 178506354, compound

HRID 408744Notes

Reaction equation

HRID 408744 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([O:10][C:11]([F:14])([F:13])[F:12])[C:7]([N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[CH:6][C:5]=1[NH2:21])([O-])=O.S(S([O-])=O)([O-])=O.[Na+].[Na+].[CH:30](OC)(OC)OC.CN(C=O)C>C(O)(=O)C>[N:15]1([C:7]2[C:8]([O:10][C:11]([F:14])([F:13])[F:12])=[CH:9][C:4]3[NH:1][CH:30]=[N:21][C:5]=3[CH:6]=2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 9005Trimethyl orthoformateHCID 24489Sodium DithioniteHCID 66937403HCID 66937403, compound

Product 1

HCID 178506354HCID 178506354, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2-nitro-5-piperidin-1-yl-4-trifluoromethoxy-phenylamine (0.900 g, 2.94 mmol), sodium dithionite (2.67 g, 15.3 mmol), trimethyl orthoformate (8.72 mL, 79.6 mmol), DMF (8.56 mL), and acetic acid (1.45 mL) was heated in a sealed tube for 15 h at 100° C. The reaction mixture was cooled to 23° C. and partitioned between EtOAc (80 mL) and saturated aqueous NaHCO3 (80 mL). The organic layer was collected and the aqueous layer was extracted with EtOAc (2×80 mL). The combined organic layers were dried, filtered, and concentrated under reduced pressure. The residue was purified (FCC) (0-15% MeOH/DCM) to yield the titled compound (0.589 g, 71%). MS (ESI/CI): mass calcd. for C13H14F3N3O, 285.1; m/z found, 286.1 [M+H]+.

Workup

  1. temperatureThe reaction mixture was cooled to 23° C.
  2. custompartitioned between EtOAc (80 mL) and saturated aqueous NaHCO3 (80 mL)
  3. customThe organic layer was collected
  4. extractionthe aqueous layer was extracted with EtOAc (2×80 mL)
  5. customThe combined organic layers were dried
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure
  8. customThe residue was purified (FCC) (0-15% MeOH/DCM)

Sources & evidence

ORD record
ord-7501a12ba4334f92bde93f3300f6ef97
Source dataset
uspto-grants-2014_06
Patent number
US08759345B2

Reaction notes

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