Piperazine → HCID 23128690, compound

Participants

Reaction Steps

In Step 3, a 6-chloropurine (4) undergoes a displacement reaction with a piperazine (5) to provide a piperazinyl purine of Formula (I). The reaction can proceed in the presence of a suitable base, such as triethylamine or diisopropylethylamine, in a solvent such as methanol, ethanol, or isopropanol, at an elevated temperature such as about 50 to 100° C. Alternatively the reaction can be accomplished using microwave irradiation.

Provenance & Evidence