Piperazine → HCID 23128690, compound

HRID 408806Notes

Reaction equation

HRID 408806 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[NH:4][CH:5]=[N:6]2.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>>[N:11]1([C:9]2[N:8]=[C:7]3[C:3]([NH:4][CH:5]=[N:6]3)=[CH:2][N:10]=2)[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 53592776-Chloropurine

Product 1

HCID 23128690HCID 23128690, compound

Procedure

In Step 3, a 6-chloropurine (4) undergoes a displacement reaction with a piperazine (5) to provide a piperazinyl purine of Formula (I). The reaction can proceed in the presence of a suitable base, such as triethylamine or diisopropylethylamine, in a solvent such as methanol, ethanol, or isopropanol, at an elevated temperature such as about 50 to 100° C. Alternatively the reaction can be accomplished using microwave irradiation.

Sources & evidence

ORD record
ord-570a16ead27d49ca962c5c80dda45d79
Source dataset
uspto-grants-2014_06
Patent number
US08759360B2

Reaction notes

Loading…